Paving the Path to Effective Translation: Exploring Preclinical Models of Genetic & Acquired Inner Ear Hearing Loss & Measuring Toxicology Profiles for Efficient Translation into the Clinic
Time: 10:10 am
day: Workshop Day
Details:
As with other isolated systems, like the brain and the eye, accessibility to the inner ear poses a challenge in extracting samples to develop in vitro models. Furthermore, current animal models such as mice, guinea pigs and monkeys are only able to recapitulate the human inner ear to a certain extent.
This workshop will:
- Bridge the gap and overcome challenges when developing animal models for genetic and acquired hearing loss
- Uncover the lack in current in vivo models of the inner ear, unable to recapitulate the cochlear hair cells, supporting cells, spiral ganglion neurons, vestibular hair cells and stria vascularis cells
- Understand the differences in size, anatomy and organization of the inner ear between in vivo models (such as mice, rates, guinea pigs, cats and monkeys) and humans, as well as differences in frequency, hearing range, lifespan and cellular composition
- Explore novel in vitro models, such as organoids and iPSCs for better replication of the human inner ear and how these models could pave the way towards a patient-centric approach
- Strategize how to optimize safety studies and validate non-conventional species are essential for overcoming regulatory barriers and fostering confidence in the development of inner ear therapeutics
